Dosage of Methotrexate for Psoriasis | Methotrexate for Psoriasis Treatment!

Methotrexate for Psoriasis.


Methotrexate is a medication that is taken orally once a week or in 3 divided doses taken at 12-hour intervals over a 24-hour period. It can also be given as an injection, once a week.

Methotrexate for Psoriasis
Methotrexate for Psoriasis

How does it work?. Methotrexate slows the rapid growth of skin cells in psoriasis.

Why is it used?

Methotrexate is used to treat severe psoriasis (more than 20% of the skin is affected) and when creams, ointments, tar products, and phototherapy have not worked or can not be used. It is also used to treat psoriatic arthritis.


Methotrexate can not be used by women who are pregnant or trying to get pregnant or by people:


  • With severe blood disorders or anemia.
  • With ulcers in the stomach.
  • With diseases of the liver or kidney.
  • With an infectious disease, like tuberculosis.
  • Those who drink alcohol frequently.
  • Those who can not return to the doctor for tests for side effects of the medicine.


How well does it work?

Methotrexate takes several weeks to show benefits. If side effects can be tolerated, methotrexate may work very well for some people. If you are taking methotrexate, blood tests should be carefully monitored. And it is very important that you do not drink alcohol.

Side effects!

Common side effects include:


  • Nausea, fatigue, loss of appetite.
  • Trouble sleeping.
  • Low blood counts.


Less common side effects include:


  • Sunburns if exposed to large doses of sunlight or ultraviolet (UV) light either before or after taking the medicine.
  • Vomiting, diarrhea, and sometimes blood in the stool.
  • Sores in the mouth.
  • Bruising and bleeding.
  • Rash on the skin or ulcers.
  • The headaches.
  • Chills and fever.
  • Dizziness.
  • Birth defects (if taken by a woman who is pregnant or becomes pregnant while taking the medication).


Long-term side effects include liver damage. If it is not serious, the damage is reversed after stopping methotrexate. The risk of liver damage is higher if you drink too much alcohol, liver or kidney problems, diabetes, or are overweight.

Because it can cause serious side effects, methotrexate is used only to treat severe psoriasis that can not be treated with other medications, such as psoriasis associated with arthritis (psoriatic arthritis).

People taking methotrexate need to have their blood counts and liver function tested before they start taking the drug and regularly while taking it.

As was clear in the article, this type of medication for psoriasis should only be administered by a professional and should be closely monitored due to the side effects that can be serious.

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methotrexate for psoriasis dose

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